![]() Esterification of estradiol to estradiol cypionate or valerate increases the parenteral duration of action of estradiol to allow for parenteral intramuscular administration. 1 Due to almost complete first-pass metabolism, estradiol must be given in a micronized oral dosage form to ensure therapeutic effect. There is no evidence that 'natural' estrogens are more or less efficacious or safe than 'synthetic' estrogens. Estradiol can be obtained from natural sources or prepared synthetically. Overview of Biest (Estriol / Estradiol) Cream Dosage Strengths of Biest CreamĮstriol / Estradiol (50/50) Multiple StrengthsĮstriol / Estradiol (70/30) Multiple StrengthsĮstriol / Estradiol (80/20) Multiple Strengths General InformationĮstradiol is the principal intracellular human estrogen and is substantially more active than its metabolites, estrone and estriol, at the cellular level.
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